2009

Wong AC, Sandesara RG, Mulherkar N, Whelan SP, Chandran K. A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry. J. Virol. [Epub ahead of print]. (pdf) (Supplementary material)

2008

Ivanovic T, Agosto MA, Zhang L, Chandran K, Harrison SC, Nibert ML. Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J. 27:1289-1298. (pdf)

2007

Ivanovic, T, Agosto, MA, Chandran, K, Nibert ML. A role for molecular chaperone Hsc70 in reovirus outer-capsid disassembly. J. Biol. Chem. 282:12210-12219. (pdf)

2006

Zhang L, Chandran K, Nibert ML, Harrison SC. Reovirus mu1 structural rearrangements that mediate membrane penetration. J. Virol. 24:12367-12376. (pdf)

Coffey CM, Sheh A, Kim IS, Chandran K, Nibert ML, Parker JS. Reovirus outer capsid protein mu1 induces apoptosis and associates with lipid droplets, endoplasmic reticulum, and mitochondria. J. Virol. 80:8422-8438. (pdf)

2005

Chandran K, Sullivan, NJ, Felbor, U, Whelan, SP, Cunningham, JM. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308:1643-1645. (pdf) (Supplementary material) (Commentary in New Engl. J. Med.) (NIH press release)

Nibert ML, Odegard AL, Agosto MA, Chandran K, Schiff LA. Putative autocleavage of reovirus mu1 protein in concert with outer-capsid disassembly and activation for membrane permeabilization. J. Mol. Biol. 345:461-474. (pdf)

2004

Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 118:591-605. (pdf)

Odegard AL, Chandran K, Zhang X, Parker JS, Baker TS, Nibert ML. Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide mu1N during particle uncoating, is critical for cell entry by reovirus. J. Virol. 78:8732-8745. (pdf)

Hutchings AB, Helander A, Silvey KJ, Chandran K, Lucas WT, Nibert ML, Neutra MR. Secretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches. J. Virol. 78:947-957. (pdf)

2003

Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML. The delta region of outer-capsid protein mu1 undergoes conformational change and release from reovirus particles during cell entry. J. Virol. 77:13361-13375. (pdf)

Chandran K, Nibert ML. Animal cell invasion by a large nonenveloped virus: reovirus delivers the goods. Trends Microbiol. 11:374-382. Review. (pdf)

Helander A, Silvey KJ, Mantis NJ, Hutchings AB, Chandran K, Lucas WT, Nibert ML, Neutra MR. The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces. J. Virol. 77:7964-7977. (pdf)

Odegard AL, Chandran K, Liemann S, Harrison SC, Nibert ML. Disulfide bonding among mu1 trimers in mammalian reovirus outer capsid: a late and reversible step in virion morphogenesis. J. Virol. 77:5389-5400. (pdf)

2002

Chandran K, Farsetta DL, Nibert ML. Strategy for nonenveloped virus entry: a hydrophobic conformer of the reovirus membrane penetration protein mu1 mediates membrane disruption. J. Virol. 76:9920-9933. (pdf)

Liemann S, Chandran K, Baker TS, Nibert ML, Harrison SC. Structure of the reovirus membrane-penetration protein, mu1, in a complex with is protector protein, sigma3. Cell 108:283-295. (pdf)

Middleton JK, Severson TF, Chandran K, Gillian AL, Yin J, Nibert ML. Thermostability of reovirus disassembly intermediates (ISVPs) correlates with genetic, biochemical, and thermodynamic properties of major surface protein mu1. J. Virol. 76:1051-1061. (pdf)

2001-1998

Chandran K, Zhang X, Olson NH, Walker SB, Chappell JD, Dermody TS, Baker TS, Nibert ML. 2001. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J. Virol. 75:5335-5342. (pdf)

Farsetta DL, Chandran K, Nibert ML. 2000. Transcriptional activities of reovirus RNA polymerase in recoated cores. Initiation and elongation are regulated by separate mechanisms. J. Biol. Chem. 275:39693-39701. (pdf)

Chandran K, Walker SB, Chen Y, Contreras CM, Schiff LA, Baker TS, Nibert ML. 1999. In vitro recoating of reovirus cores with baculovirus-expressed outer-capsid proteins mu1 and sigma3. J. Virol. 73:3941-3950. (pdf)

Chandran K, Nibert ML. 1998. Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle. J. Virol. 72:467-475. (pdf)