Research Interests

Viral infection is war between virus and host waged at the molecular level. The Chandran Lab seeks to uncover the detailed battle plans for the first phase of this conflict, in which viruses invade host cells to gain access to the cytoplasm, where the resources necessary for constructing new viruses are located.

We study highly pathogenic emerging viruses for which no treatments are currently available. Our current efforts are focused on filoviruses (e.g., Ebola virus and Marburg virus) and hantaviruses (e.g., Sin Nombre virus). Insights into how viruses exploit their hosts yield targets for development of antiviral treatments, and we vigorously explore such opportunities through wide-ranging collaborations.

Check out our research blog below for our key research findings, how they came about, and their implications. Click on the post title to read the paper's abstract and download manuscript PDFs, and on 'Read More' to view the blog entry and post comments. Subscribe to our RSS feed below.