Our student, Lara, helped elucidate the mode of action of the human antibodies by demonstrating inhibition of viral fusion in cells through stabilization of the pre-fusion conformation of the Lassa virus glycoprotein.
Check out a highlight of our work on pan-ebolavirus neutralizing antibodies in the NIH Research Matters newsletter.
“Since it’s impossible to predict which of these agents will cause the next epidemic, it would be ideal to develop a single therapy that could treat or prevent infection caused by any known ebolavirus,” - Zach Bornholdt, PhD
Read about how our NIAID-funded study could lead to broad, versatile treatments for many different Ebolaviruses.
Researchers funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have studied the blood of an Ebola survivor, searching for human antibodies that might effectively treat not only people infected with Ebola virus, but those infected with related viruses as well. Now the researchers have identified two such antibodies that hold promise as Ebola treatments.
A research preview by Seiya Yamayoshi and Yoshihiro Kawaoka in Cell, describing two of our collaborative stories published in the May 18, 2017 issue of the journal.
Commentary in Nature highlights the power of cross-institutional collaborations and lessons learned by the team as they make headway on finding better treatments for Ebola virus infection. The Chandran Lab is an integral part of the Viral Hemorrhagic Fever Immunotherapeutic Consortium, contributing key functional assays that characterize neutralization activity of monoclonal antibodies and help predict their therapeutic potential.
Like a Trojan horse, Ebola virus sneaks into a human cell by hiding out inside lysosomes. In order to escape from the lysosome, the virus must then fuse its membrane with the membrane of the lysosome. Live imaging captures this moment of fusion in brilliant color. Images by Chandran Lab postdoctoral fellow, Dr. Jennifer Spence.
This 3D animation shows how Ebola virus exploits a naturally occurring protein in our cells called NPC1 to cause infection and spread in the body. Narrated by Kartik.
Kartik explains the novel strategies he and his colleagues are using to develop treatments for Ebola virus infections. Watch 3D animations showing how Ebola enters a cell and delivers its payload in order to replicate and spread throughout the body.
Episode 314 of Dr. Vincent Racaniello's world-famous virology blog, This Week in Virology (TWiV), features Kartik and two other Einstein virologists, Margaret Kielian and Ganjam Kalpana. Filmed before a live audience in Einstein's Price Center Auditorium. Watch the video (1 hour, 26 mins).