Complete bibliography: Pubmed | @Google Scholar

2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017   2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

 

2026

Featured
Expanded protocadherin-1 usage reveals a broader hantavirus entry landscape
Expanded protocadherin-1 usage reveals a broader hantavirus entry landscape

Word et al, bioRxiv 2026

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Finding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccine
Finding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccine

Berrigan et al, bioRxiv 2026

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Powassan Virus Seroprevalence in a U.S. Servicemember Population at High Risk for Tick Exposure
Powassan Virus Seroprevalence in a U.S. Servicemember Population at High Risk for Tick Exposure

Tse et al, medRxiv 2026

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Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth
Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth

Wang et al, Res Sq 2026

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Protective human antibodies against Powassan virus
Protective human antibodies against Powassan virus

Fallon et al, J Virol 2026

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Structural Dynamics and Allosteric Communication of a SARS-Like Bat Coronavirus Spike Glycoprotein
Structural Dynamics and Allosteric Communication of a SARS-Like Bat Coronavirus Spike Glycoprotein

Balogun et al, Biophys J 2026

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High-resolution in situ structures of hantavirus glycoprotein tetramers
High-resolution in situ structures of hantavirus glycoprotein tetramers

Guo et al, Cell 2026

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RASP: rapid antibody functional screening by pentavalent phage display
RASP: rapid antibody functional screening by pentavalent phage display

Kaur et al, mAbs 2026

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Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection
Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection

Clark et al, EBiomedicine 2026

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2025

Featured
Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine Development
Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine Development

Huang et al, Adv Sci (Weinh) 2025

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Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding

Tse et al, PLoS Pathog 2025

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LRP8 is a receptor for tick-borne encephalitis virus
LRP8 is a receptor for tick-borne encephalitis virus

Mittler et al, Nature 2025

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Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple families
Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple families

Mofed et al, mBio 2025

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Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus
Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus

Wang et al, mBio 2025

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SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)
SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)

Dada et al, Front Immunol 2025

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Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

Pahmeier et al, Sci Transl Med 2025

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Structural insights into tecovirimat antiviral activity and poxvirus resistance
Structural insights into tecovirimat antiviral activity and poxvirus resistance

Vernuccio et al, Nat Microbiol 2025

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Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes
Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes

McFadden et al, Cell 2024

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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning
Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Lasso et al, Cell Host & Microbe 2025

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2024

Featured
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Tse et al, PLoS Pathog 2024

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MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination
MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination

Selverian et al, J Infect Dis 2024

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Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens
Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens

Nuqui et al, Nat Commun 2024

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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Shin et al, Cell Rep 2024

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A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus
A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus

Ng et al, Front Immunol 2024

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Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

Jing et al, Elife 2024

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A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants
A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants

Yang et al, Antib Ther 2024

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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies
Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Wirchnianski et al, PLoS Pathog 2024

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Case of Human Orthohantavirus Infection, Michigan, USA, 2021
Case of Human Orthohantavirus Infection, Michigan, USA, 2021

Goodfellow et al, Emerg Infect Dis 2024

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Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- multivalent adjuvanted glycoprotein vaccines
Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- multivalent adjuvanted glycoprotein vaccines

Felgner et al, Antiviral Res 2024

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Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence
Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence

Pathak et al, Viruses 2024

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Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge

Hsieh C-L et al, Nat Commun 2024

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2023

Featured
Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection

Slough MM et al, Nat Commun 2023

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Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody
Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

Mittler E et al, Science Transl Med 2023

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A Pan-ebolavirus Monoclonal Antibody Cocktail Provides Protection against Ebola and Sudan Viruses
A Pan-ebolavirus Monoclonal Antibody Cocktail Provides Protection against Ebola and Sudan Viruses

Liu G et al, J Infect Dis 2023

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TNF-α Limits Serological Memory by Disrupting the Bone Marrow Niche
TNF-α Limits Serological Memory by Disrupting the Bone Marrow Niche

Aaron T et al, J Immunol 2023

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2022

Featured
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2

Cheshenko N et al, Commun Biol 2022

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Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference
Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference

Fels JM et al, Cold Spring Harb Mol Case Stud 2022

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A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice
A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice

Malonis RJ et al, PLoS Pathog 2022

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Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals
Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals

Muena N et al, EBiomedicine 2022

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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Mittler E et al, Science Transl Med 2022

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Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies

Haslwanter D et al, Cell Host Microbe 2022

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Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial

Ortigoza MB et al, JAMA Internal Med 2022

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Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes
Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes

Lasso G et al, PLoS Comput Biol 2022

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Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies
Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies

Mishra AK et al, Science 2022

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2021

Featured
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Herman JD et al, Nature Communications 2022

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Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity
Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

Wirchnianski AS et al, Front Immunol 2021

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A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

Haslwanter D & Dieterle ME et al, mBio 2021

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Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses
Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses

Malonis RJ et al, Proc Natl Acad Sci 2021

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting

Forest SK et al, Arch Pathol Lab Med 2021

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Generation of plasma cells and CD27 - IgD - B cells during hantavirus infection is associated with distinct pathological findings
Generation of plasma cells and CD27 - IgD - B cells during hantavirus infection is associated with distinct pathological findings

Kerkman PF et al, Clin Transl Immunol 2021

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Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells
Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

Dieterle ME et al, eLife 2021

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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever

Fels JM et al, Cell 2021

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MAVERICC: Marker-free Vaccinia Virus Engineering of Recombinants through in vitro CRISPR/Cas9 Cleavage
MAVERICC: Marker-free Vaccinia Virus Engineering of Recombinants through in vitro CRISPR/Cas9 Cleavage

Laudermilch E et al, J Mol Biol 2021

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Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts
Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts

Bortz RH III et al, mSphere 2021

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The shape of pleomorphic virions determines resistance to cell-entry pressure
The shape of pleomorphic virions determines resistance to cell-entry pressure

Li T et al, Nat Microbiol 2021

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Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC
Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC

Yoon HA et al, JCI Insight 2021

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A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion
A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion

JM Fels et al, mBio 2021

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The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

Wells HL et al, Virus Evol 2021

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Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization
Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization

Wang Y et al, mBio 2021

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Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity Ligation
Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity Ligation

Mittler E et al, mBio 2021

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2020

Featured
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

Herrera NG et al, ACS Omega 2020

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The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism
The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism

Serris A et al, Cell 2020

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Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Pierce CA et al, Sci Transl Med 2020

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A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition
A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition

Bortz RH III et al, J Virol 2020

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HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses
HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

Burn Aschner C et al, Sci Immunoi 2020

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Broad neutralization of SARS-related viruses by human monoclonal antibodies
Broad neutralization of SARS-related viruses by human monoclonal antibodies

Wec AZ et al, Science 2020

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Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice
Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice

Warner BM et al, Front Cell Infect Microbiol 2020

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Exploiting Pre-Existing CD4 + T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses
Exploiting Pre-Existing CD4 + T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses

Ng TW et al, J Immunol 2020

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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition
A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

Dieterle ME & Haslwanter D et al, Cell Host Microbe 2020

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Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

Wu X et al, Cell Chem Biol 2020

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2019

Featured
Hantavirus entry: Perspectives and recent advances
Hantavirus entry: Perspectives and recent advances

Mittler E et al, Adv Virus Res 2019

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Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses.
Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses.

Warner BM et al, Viruses 2019

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A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry
A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

Fels JM et al, mBio 2019

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Human, nonhuman primate, and bat Cells Are broadly susceptible to tibrovirus particle cell entry
Human, nonhuman primate, and bat Cells Are broadly susceptible to tibrovirus particle cell entry

Cai C et al, Front Microbiol 2019

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Structural basis of broad ebolavirus neutralization by a human survivor antibody
Structural basis of broad ebolavirus neutralization by a human survivor antibody

West BR & Wec AZ et al, Nat Struct Mol Biol 2019

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Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus
Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus

Dong F, NPJ Vaccines 2019

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IFITM3 directly engages and shuttles incoming virus particles to lysosomes
IFITM3 directly engages and shuttles incoming virus particles to lysosomes

Spence JS et al, Nature Chem Bio  2019

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Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Wec AZ et al, Cell Host Microbe 2019

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A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt ZA et al, Cell Host Microbe 2019

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Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors
Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors

Slough MM et al, mBio 2019

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2018

Featured
Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.
Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.

Fedewa G et al, Virus Evol 2018

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Protocadherin-1 is essential for cell entry by New World hantaviruses
Protocadherin-1 is essential for cell entry by New World hantaviruses

Jangra RK et al, Nature 2018

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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses
The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Goldstein T et al, Nat Microbiol 2018

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Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Saphire EO et al, Cell 2018

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A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn BM et al, Cell Host Microbe 2018

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A naturally occurring antiviral ribonucleotide encoded by the human genome
A naturally occurring antiviral ribonucleotide encoded by the human genome

Gizzi AS et al, Nature 2018

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Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins
Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura EK et al, J Biol Chem 2018

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2017

Featured
Structural basis for antibody-mediated neutralization of Lassa virus
Structural basis for antibody-mediated neutralization of Lassa virus

Hastie KM et al, Science 2017

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Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability
Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao X et al, Cell 2017

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Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

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2016

2016–2017
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

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Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell KA et al, Cell Rep 2016

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A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

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Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

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Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

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Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses
Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

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Cysteine cathepsin inhibitors as anti-Ebola agents
Cysteine cathepsin inhibitors as anti-Ebola agents

van der Linden W et al, ACS Infect Dis 2016

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2015

2014–2015
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

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Novel small molecule entry inhibitors of Ebola virus
Novel small molecule entry inhibitors of Ebola virus

Basu A et al, J Infect Dis 2015

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Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

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Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo
Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

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Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

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Filovirus entry into susceptible cells
Filovirus entry into susceptible cells

Jangra RK, Biology of Rhabdo- and Filoviruses  2015

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2014

Featured
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

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Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge
Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

Chen G, Koellhoffer JF, Zak SE et al, ACS Chem Biol 2014

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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants
A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Jacobson J et al, PLoS One 2014

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Comprehensive functional analysis of N-linked glycans on Ebola virus GP1
Comprehensive functional analysis of N-linked glycans on Ebola virus GP1

Lennemann NJ et al, MBio 2014

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Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species

Koellhoffer JF, Dai Z et al, J Mol Biol 2014

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2013

2012–2013
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima H, Jacobson LS et al, Cell Cycle 2013

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Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids
Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids

Regula LK, Harris R et al, Biochemistry 2013

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A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner
A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner

Martinez O et al, J Virol 2013

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Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

Jacobson LS et al, J Biol Chem 2013

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2012

Featured
Endocytic pathways involved in filovirus entry: advances, implications and future directions
Endocytic pathways involved in filovirus entry: advances, implications and future directions

Bhattacharyya S et al, Viruses 2012

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Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein
Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein

Koellhoffer JF, Chen G et al, Chembiochem 2012

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NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor
NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Krishnan A et al, Viruses 2012

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Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation
Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation

Koellhoffer JF et al, Biochemistry 2012

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Structural basis for differential neutralization of ebolaviruses
Structural basis for differential neutralization of ebolaviruses

Bale S, Dias JM et al, Viruses 2012

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Filovirus entry into cells—new insights
Filovirus entry into cells—new insights

Miller and Chandran, Curr Opin Virol 2012

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Ebola virus entry requires the host-programmed recognition of an intracellular receptor
Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Miller EH, Obernosterer G, Raaben M, Herbert AS et al, EMBO J 2012

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Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle
Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle

Harrison JS et al, Biochemistry 2012

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2011

2010–2011
Filoviruses require endosomal cysteine proteases for entry but display distinct protease preferences
Filoviruses require endosomal cysteine proteases for entry but display distinct protease preferences

Misasi J, Chandran K et al, J Virol 2012

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The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway
The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

Mulherkar N et al, Virology 2011

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Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Carette JE, Raaben M, Wong AC et al, Nature 2011

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Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects
Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects

Harrison JS, Higgins CD et al, Protein Sci 2011

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Inhibition of Ebola virus entry by a C-peptide targeted to endosomes
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

Miller EH, Harrison JS et al, J Biol Chem 2011

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Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles
Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles

Martinez O et al, J Infect Dis 2011

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2010

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A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry
A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry

Wong AC et al, J Virol 2010

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