March 04, 2019

Structural basis of broad ebolavirus neutralization by a human survivor antibody→

March 04, 2019/ Kartik Chandran

Structural basis of broad ebolavirus neutralization by a human survivor antibody

West BR & Wec AZ et al, Nat Struct Mol Biol 2019

January 25, 2019

Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus→

January 25, 2019/ Kartik Chandran

Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus

Dong F, NPJ Vaccines 2019

January 14, 2019

IFITM3 directly engages and shuttles incoming virus particles to lysosomes→

January 14, 2019/ Kartik Chandran

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

Spence JS et al, Nature Chem Bio 2019

January 09, 2019

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection→

January 09, 2019/ Kartik Chandran

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Wec AZ et al, Cell Host Microbe 2019

January 09, 2019

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates→

January 09, 2019/ Kartik Chandran

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt ZA et al, Cell Host Microbe 2019

January 08, 2019

Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors→

January 08, 2019/ Kartik Chandran

Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors

Slough MM et al, mBio 2019

November 28, 2018

Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.→

November 28, 2018/ Kartik Chandran

Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.

Fedewa G et al, Virus Evol 2018

November 22, 2018

Protocadherin-1 is essential for cell entry by New World hantaviruses→

November 22, 2018/ Kartik Chandran

Protocadherin-1 is essential for cell entry by New World hantaviruses

Jangra RK et al, Nature 2018

August 27, 2018

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses→

August 27, 2018/ Kartik Chandran

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Goldstein T et al, Nat Microbiol 2018

August 09, 2018

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection→

August 09, 2018/ Kartik Chandran

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Saphire EO et al, Cell 2018

August 08, 2018

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus→

August 08, 2018/ Kartik Chandran

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn BM et al, Cell Host Microbe 2018

June 20, 2018

A naturally occurring antiviral ribonucleotide encoded by the human genome→

June 20, 2018/ Kartik Chandran

A naturally occurring antiviral ribonucleotide encoded by the human genome

Gizzi AS et al, Nature 2018

March 01, 2018

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins→

March 01, 2018/ Kartik Chandran

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura EK et al, J Biol Chem 2018

June 02, 2017

Structural basis for antibody-mediated neutralization of Lassa virus→

June 02, 2017/ Kartik Chandran

Structural basis for antibody-mediated neutralization of Lassa virus

Hastie KM et al, Science 2017

May 18, 2017

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability→

May 18, 2017/ Kartik Chandran

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao X et al, Cell 2017

May 18, 2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses→

May 18, 2017/ Kartik Chandran

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

May 05, 2016

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site→

May 05, 2016/ Kartik Chandran

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell KA et al, Cell Rep 2016

March 30, 2016

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→

March 30, 2016/ Kartik Chandran

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016