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The Chandran Lab
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  • news & media/
  • research/
  • team/
  • publications/
  • find us/
  • positions/
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The Chandran Lab

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The Chandran Lab
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September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

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September 08, 2016/ Kartik Chandran/ Comment /Source
2016-2017, Ebola virus, filovirus, therapeutics, antibody, host factors, NPC1, antivirals, researchpage, 2016
February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

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February 23, 2016/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, NPC1, host factors, receptors, antibody, 2016-2017, researchpage, 2016
January 29, 2016

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses→

January 29, 2016/ Kartik Chandran
Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

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January 29, 2016/ Kartik Chandran/ Comment /Source
2016-2017, GP, antibody, therapeutics, Ebola virus, filovirus, 2016
August 20, 2014

Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge→

August 20, 2014/ Kartik Chandran
Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

Chen G, Koellhoffer JF, Zak SE et al, ACS Chem Biol 2014

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August 20, 2014/ Kartik Chandran/ Comment /Source
therapeutics, antibody, GP, pathogenesis, animal model, 2014–2015, filovirus, 2014
October 30, 2012

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein→

October 30, 2012/ Kartik Chandran
Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein

Koellhoffer JF, Chen G et al, Chembiochem 2012

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October 30, 2012/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, 2012–2013, researchpage, 2012
April 05, 2012

Structural basis for differential neutralization of ebolaviruses→

April 05, 2012/ Kartik Chandran
Structural basis for differential neutralization of ebolaviruses

Bale S, Dias JM et al, Viruses 2012

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April 05, 2012/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, 2012–2013, 2012
November 20, 2011

A shared immunological solution for neutralization of ebolaviruses→

November 20, 2011/ Kartik Chandran
A shared immunological solution for neutralization of ebolaviruses

Dias JM et al, Nat Struct Mol Biol 2011

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November 20, 2011/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, membrane fusion, 2010–2011
February 01, 2011

Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles→

February 01, 2011/ Kartik Chandran
Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles

Martinez O et al, J Infect Dis 2011

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February 01, 2011/ Kartik Chandran/ Comment /Source
filovirus, Ebola virus, antibody, animal model, 2010–2011, 2011

© 2015, Kartik Chandran Laboratory