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The Chandran Lab

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August 30, 2012

Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation→

August 30, 2012/ Kartik Chandran
Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation

Koellhoffer JF et al, Biochemistry 2012

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August 30, 2012/ Kartik Chandran/ 1 Comment /Source
2012–2013, filovirus, Ebola virus, membrane fusion, 2012
April 05, 2012

Structural basis for differential neutralization of ebolaviruses→

April 05, 2012/ Kartik Chandran
Structural basis for differential neutralization of ebolaviruses

Bale S, Dias JM et al, Viruses 2012

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April 05, 2012/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, 2012–2013, 2012
March 06, 2012

Ebola virus entry requires the host-programmed recognition of an intracellular receptor→

March 06, 2012/ Kartik Chandran
Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Miller EH, Obernosterer G, Raaben M, Herbert AS et al, EMBO J 2012

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March 06, 2012/ Kartik Chandran/ Comment /Source
2012–2013, Ebola virus, filovirus, host factors, receptors, NPC1, 2012
February 27, 2012

Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle→

February 27, 2012/ Kartik Chandran
Marburg Virus Glycoprotein GP2: pH-Dependent Stability of the Ectodomain Alpha-Helical Bundle

Harrison JS et al, Biochemistry 2012

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February 27, 2012/ Kartik Chandran/ 1 Comment /Source
filovirus, Ebola virus, membrane fusion, 2012–2013, 2012
January 11, 2012

Filoviruses require endosomal cysteine proteases for entry but display distinct protease preferences→

January 11, 2012/ Kartik Chandran
Filoviruses require endosomal cysteine proteases for entry but display distinct protease preferences

Misasi J, Chandran K et al, J Virol 2012

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January 11, 2012/ Kartik Chandran/ 1 Comment /Source
filovirus, host factors, cathepsin, Ebola virus, 2012–2013, researchpage, 2011
November 20, 2011

A shared immunological solution for neutralization of ebolaviruses→

November 20, 2011/ Kartik Chandran
A shared immunological solution for neutralization of ebolaviruses

Dias JM et al, Nat Struct Mol Biol 2011

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November 20, 2011/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, membrane fusion, 2010–2011
September 09, 2011

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway→

September 09, 2011/ Kartik Chandran
The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

Mulherkar N et al, Virology 2011

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September 09, 2011/ Kartik Chandran/ Comment /Source
filovirus, Ebola virus, host factors, 2010–2011, researchpage, 2011
August 24, 2011

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection→

August 24, 2011/ Kartik Chandran
Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

Côté M, Misasi J, Ren T, Bruchez A et al, Nature 2011

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August 24, 2011/ Kartik Chandran/ Comment /Source
2010–2011, filovirus, researchpage
June 25, 2011

Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects→

June 25, 2011/ Kartik Chandran
Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects

Harrison JS, Higgins CD et al, Protein Sci 2011

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June 25, 2011/ Kartik Chandran/ 1 Comment /Source
Ebola virus, filovirus, membrane fusion, 2010–2011, 2011
May 06, 2011

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes→

May 06, 2011/ Kartik Chandran
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

Miller EH, Harrison JS et al, J Biol Chem 2011

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May 06, 2011/ Kartik Chandran/ Comment /Source
filovirus, Ebola virus, membrane fusion, antivirals, 2010–2011, researchpage, 2011
February 01, 2011

Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles→

February 01, 2011/ Kartik Chandran
Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles

Martinez O et al, J Infect Dis 2011

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February 01, 2011/ Kartik Chandran/ Comment /Source
filovirus, Ebola virus, antibody, animal model, 2010–2011, 2011
January 01, 2010

A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry→

January 01, 2010/ Kartik Chandran
A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry

Wong AC et al, J Virol 2010

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January 01, 2010/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, cathepsin, host factors, membrane fusion, 2010–2011, researchpage, 2010
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