May 18, 2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses→

May 18, 2017/ Kartik Chandran

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

May 05, 2016

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site→

May 05, 2016/ Kartik Chandran

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell KA et al, Cell Rep 2016

March 30, 2016

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→

March 30, 2016/ Kartik Chandran

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

February 09, 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway→

February 09, 2016/ Kartik Chandran

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

January 29, 2016

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses→

January 29, 2016/ Kartik Chandran

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

January 20, 2016

Cysteine cathepsin inhibitors as anti-Ebola agents→

January 20, 2016/ Kartik Chandran

Cysteine cathepsin inhibitors as anti-Ebola agents

van der Linden W et al, ACS Infect Dis 2016

December 23, 2015

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats→

December 23, 2015/ Kartik Chandran

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

July 22, 2015

Novel small molecule entry inhibitors of Ebola virus→

July 22, 2015/ Kartik Chandran

Novel small molecule entry inhibitors of Ebola virus

Basu A et al, J Infect Dis 2015

June 03, 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion→

June 03, 2015/ Kartik Chandran

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

May 26, 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo→

May 26, 2015/ Kartik Chandran

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

April 01, 2015

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents→

April 01, 2015/ Kartik Chandran

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

March 02, 2015

Filovirus entry into susceptible cells→

March 02, 2015/ Kartik Chandran

Filovirus entry into susceptible cells

Jangra RK, Biology of Rhabdo- and Filoviruses 2015

October 11, 2014

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1→

October 11, 2014/ Kartik Chandran

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

August 20, 2014

Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge→

August 20, 2014/ Kartik Chandran

Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

Chen G, Koellhoffer JF, Zak SE et al, ACS Chem Biol 2014

June 03, 2014

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants→

June 03, 2014/ Kartik Chandran

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Jacobson J et al, PLoS One 2014

January 28, 2014

Comprehensive functional analysis of N-linked glycans on Ebola virus GP1→

January 28, 2014/ Kartik Chandran

Comprehensive functional analysis of N-linked glycans on Ebola virus GP1

Lennemann NJ et al, MBio 2014

December 12, 2013

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species→

December 12, 2013/ Kartik Chandran

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species

Koellhoffer JF, Dai Z et al, J Mol Biol 2014

August 02, 2013

C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking→

August 02, 2013/ Kartik Chandran

C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking

Higgins CD et al, Bioorg Med Chem Lett 2013