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  • news & media/
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  • team/
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The Chandran Lab

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The Chandran Lab
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August 08, 2018

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus→

August 08, 2018/ Kartik Chandran
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn BM et al, Cell Host Microbe 2018

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August 08, 2018/ Kartik Chandran/ Comment /Source
researchpage, 2018
June 20, 2018

A naturally occurring antiviral ribonucleotide encoded by the human genome→

June 20, 2018/ Kartik Chandran
A naturally occurring antiviral ribonucleotide encoded by the human genome

Gizzi AS et al, Nature 2018

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June 20, 2018/ Kartik Chandran/ Comment /Source
researchpage, 2018
March 01, 2018

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins→

March 01, 2018/ Kartik Chandran
Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura EK et al, J Biol Chem 2018

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March 01, 2018/ Kartik Chandran/ Comment /Source
researchpage, 2018
June 02, 2017

Structural basis for antibody-mediated neutralization of Lassa virus→

June 02, 2017/ Kartik Chandran
Structural basis for antibody-mediated neutralization of Lassa virus

Hastie KM et al, Science 2017

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June 02, 2017/ Kartik Chandran/ Comment /Source
Lassa
researchpage, 2017
May 18, 2017

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability→

May 18, 2017/ Kartik Chandran
Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao X et al, Cell 2017

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May 18, 2017/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, host factors, receptors, NPC1, researchpage, 2017
May 18, 2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses→

May 18, 2017/ Kartik Chandran
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

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May 18, 2017/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, host factors, receptors, NPC1, researchpage, 2017
September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

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September 08, 2016/ Kartik Chandran/ Comment /Source
2016-2017, Ebola virus, filovirus, therapeutics, antibody, host factors, NPC1, antivirals, researchpage, 2016
May 05, 2016

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site→

May 05, 2016/ Kartik Chandran
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell KA et al, Cell Rep 2016

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May 05, 2016/ Kartik Chandran/ Comment /Source
2016, researchpage
March 30, 2016

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→

March 30, 2016/ Kartik Chandran
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

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March 30, 2016/ Kartik Chandran/ Comment /Source
2016, Ebola virus, filovirus, host factors, receptors, NPC1, researchpage
February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

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February 23, 2016/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, NPC1, host factors, receptors, antibody, 2016-2017, researchpage, 2016
February 09, 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway→

February 09, 2016/ Kartik Chandran
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

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February 09, 2016/ Kartik Chandran/ Comment /Source
2016-2017, Ebola virus, membrane fusion, GP, filovirus, host factors, researchpage, 2016
January 29, 2016

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses→

January 29, 2016/ Kartik Chandran
Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

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January 29, 2016/ Kartik Chandran/ Comment /Source
2016-2017, GP, antibody, therapeutics, Ebola virus, filovirus, 2016
January 20, 2016

Cysteine cathepsin inhibitors as anti-Ebola agents→

January 20, 2016/ Kartik Chandran
Cysteine cathepsin inhibitors as anti-Ebola agents

van der Linden W et al, ACS Infect Dis 2016

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January 20, 2016/ Kartik Chandran/ Comment /Source
2016-2017, cathepsin, filovirus, antivirals, Ebola virus, researchpage, 2016
December 23, 2015

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats→

December 23, 2015/ Kartik Chandran
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

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December 23, 2015/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, host factors, receptors, NPC1, researchpage, 2014–2015, 2015
July 22, 2015

Novel small molecule entry inhibitors of Ebola virus→

July 22, 2015/ Kartik Chandran
Novel small molecule entry inhibitors of Ebola virus

Basu A et al, J Infect Dis 2015

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July 22, 2015/ Kartik Chandran/ Comment /Source
Ebola virus, therapeutics, filovirus, GP, 2014–2015, antivirals, 2015
June 03, 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion→

June 03, 2015/ Kartik Chandran
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

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June 03, 2015/ Kartik Chandran/ 1 Comment /Source
hantavirus, cholesterol, membrane fusion, host factors, genetic screen, 2014–2015, researchpage, kleinfelter2015, 2015
May 26, 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo→

May 26, 2015/ Kartik Chandran
Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

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May 26, 2015/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, NPC1, pathogenesis, host, animal model, receptors, host factors, therapeutics, 2014–2015, antivirals, researchpage, 2015
April 01, 2015

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents→

April 01, 2015/ Kartik Chandran
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

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April 01, 2015/ Kartik Chandran/ Comment /Source
cathepsin, cell death, necroptosis, 2014–2015, 2015
March 02, 2015

Filovirus entry into susceptible cells→

March 02, 2015/ Kartik Chandran
Filovirus entry into susceptible cells

Jangra RK, Biology of Rhabdo- and Filoviruses  2015

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March 02, 2015/ Kartik Chandran/ Comment /Source
researchpage, 2015
October 11, 2014

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1→

October 11, 2014/ Kartik Chandran
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

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October 11, 2014/ Kartik Chandran/ Comment /Source
Ebola virus, Lloviu virus, NPC1, host factors, 2014–2015, filovirus, receptors, researchpage, 2014
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© 2015, Kartik Chandran Laboratory