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  • news & media/
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The Chandran Lab

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The Chandran Lab
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May 26, 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo→

May 26, 2015/ Kartik Chandran
Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

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May 26, 2015/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, NPC1, pathogenesis, host, animal model, receptors, host factors, therapeutics, 2014–2015, antivirals, researchpage, 2015
April 01, 2015

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents→

April 01, 2015/ Kartik Chandran
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

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April 01, 2015/ Kartik Chandran/ Comment /Source
cathepsin, cell death, necroptosis, 2014–2015, 2015
March 02, 2015

Filovirus entry into susceptible cells→

March 02, 2015/ Kartik Chandran
Filovirus entry into susceptible cells

Jangra RK, Biology of Rhabdo- and Filoviruses  2015

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March 02, 2015/ Kartik Chandran/ Comment /Source
researchpage, 2015
October 11, 2014

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1→

October 11, 2014/ Kartik Chandran
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

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October 11, 2014/ Kartik Chandran/ Comment /Source
Ebola virus, Lloviu virus, NPC1, host factors, 2014–2015, filovirus, receptors, researchpage, 2014
August 20, 2014

Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge→

August 20, 2014/ Kartik Chandran
Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

Chen G, Koellhoffer JF, Zak SE et al, ACS Chem Biol 2014

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August 20, 2014/ Kartik Chandran/ Comment /Source
therapeutics, antibody, GP, pathogenesis, animal model, 2014–2015, filovirus, 2014
June 03, 2014

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants→

June 03, 2014/ Kartik Chandran
A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Jacobson J et al, PLoS One 2014

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June 03, 2014/ Kartik Chandran/ Comment /Source
2014–2015, cathepsin, cell death, necroptosis, 2014
January 28, 2014

Comprehensive functional analysis of N-linked glycans on Ebola virus GP1→

January 28, 2014/ Kartik Chandran
Comprehensive functional analysis of N-linked glycans on Ebola virus GP1

Lennemann NJ et al, MBio 2014

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January 28, 2014/ Kartik Chandran/ Comment /Source
GP, vaccine, 2014–2015, filovirus, 2014
December 12, 2013

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species→

December 12, 2013/ Kartik Chandran
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species

Koellhoffer JF, Dai Z et al, J Mol Biol 2014

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December 12, 2013/ Kartik Chandran/ Comment /Source
arenavirus, CASV, GP, 2014–2015, membrane fusion, 2014
August 02, 2013

C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking→

August 02, 2013/ Kartik Chandran
C-Peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: Effects of conjugation to cholesterol and side chain-side chain cross linking

Higgins CD et al, Bioorg Med Chem Lett 2013

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August 02, 2013/ Kartik Chandran/ Comment /Source
filovirus, membrane fusion, antivirals
June 15, 2013

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death→

June 15, 2013/ Kartik Chandran
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima H, Jacobson LS et al, Cell Cycle 2013

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June 15, 2013/ Kartik Chandran/ Comment /Source
2012–2013, cathepsin, cell death, necroptosis, 2013
April 19, 2013

Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids→

April 19, 2013/ Kartik Chandran
Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids

Regula LK, Harris R et al, Biochemistry 2013

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April 19, 2013/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, membrane fusion, GP, 2012–2013, antivirals, 2013
January 09, 2013

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner→

January 09, 2013/ Kartik Chandran
A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner

Martinez O et al, J Virol 2013

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January 09, 2013/ Kartik Chandran/ Comment /Source
2012–2013, filovirus, NPC1, host factors, receptors, 2013
January 07, 2013

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants→

January 07, 2013/ Kartik Chandran
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

Jacobson LS et al, J Biol Chem 2013

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January 07, 2013/ Kartik Chandran/ Comment /Source
2012–2013, cathepsin, cell death, necroptosis, 2013
December 11, 2012

Endocytic pathways involved in filovirus entry: advances, implications and future directions→

December 11, 2012/ Kartik Chandran
Endocytic pathways involved in filovirus entry: advances, implications and future directions

Bhattacharyya S et al, Viruses 2012

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December 11, 2012/ Kartik Chandran/ Comment /Source
2012–2013, filovirus, host factors, receptors, review, 2012
October 30, 2012

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein→

October 30, 2012/ Kartik Chandran
Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein

Koellhoffer JF, Chen G et al, Chembiochem 2012

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October 30, 2012/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, 2012–2013, researchpage, 2012
October 25, 2012

NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor→

October 25, 2012/ Kartik Chandran
NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Krishnan A et al, Viruses 2012

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October 25, 2012/ Kartik Chandran/ Comment /Source
2012–2013, receptors, NPC1, filovirus, Ebola virus, host factors, researchpage, 2012
August 30, 2012

Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation→

August 30, 2012/ Kartik Chandran
Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation

Koellhoffer JF et al, Biochemistry 2012

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August 30, 2012/ Kartik Chandran/ 1 Comment /Source
2012–2013, filovirus, Ebola virus, membrane fusion, 2012
April 05, 2012

Structural basis for differential neutralization of ebolaviruses→

April 05, 2012/ Kartik Chandran
Structural basis for differential neutralization of ebolaviruses

Bale S, Dias JM et al, Viruses 2012

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April 05, 2012/ Kartik Chandran/ Comment /Source
Ebola virus, filovirus, antibody, 2012–2013, 2012
March 23, 2012

Filovirus entry into cells—new insights→

March 23, 2012/ Kartik Chandran
Filovirus entry into cells—new insights

Miller and Chandran, Curr Opin Virol 2012

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March 23, 2012/ Kartik Chandran/ Comment /Source
2012–2013, receptors, host factors, review, 2012
March 06, 2012

Ebola virus entry requires the host-programmed recognition of an intracellular receptor→

March 06, 2012/ Kartik Chandran
Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Miller EH, Obernosterer G, Raaben M, Herbert AS et al, EMBO J 2012

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March 06, 2012/ Kartik Chandran/ Comment /Source
2012–2013, Ebola virus, filovirus, host factors, receptors, NPC1, 2012
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