November 28, 2018

Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.→

November 28, 2018/ Kartik Chandran

Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.

Fedewa G et al, Virus Evol 2018

November 22, 2018

Protocadherin-1 is essential for cell entry by New World hantaviruses→

November 22, 2018/ Kartik Chandran

Protocadherin-1 is essential for cell entry by New World hantaviruses

Jangra RK et al, Nature 2018

August 27, 2018

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses→

August 27, 2018/ Kartik Chandran

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Goldstein T et al, Nat Microbiol 2018

August 09, 2018

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection→

August 09, 2018/ Kartik Chandran

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Saphire EO et al, Cell 2018

August 08, 2018

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus→

August 08, 2018/ Kartik Chandran

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn BM et al, Cell Host Microbe 2018

June 20, 2018

A naturally occurring antiviral ribonucleotide encoded by the human genome→

June 20, 2018/ Kartik Chandran

A naturally occurring antiviral ribonucleotide encoded by the human genome

Gizzi AS et al, Nature 2018

March 01, 2018

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins→

March 01, 2018/ Kartik Chandran

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura EK et al, J Biol Chem 2018

June 02, 2017

Structural basis for antibody-mediated neutralization of Lassa virus→

June 02, 2017/ Kartik Chandran

Structural basis for antibody-mediated neutralization of Lassa virus

Hastie KM et al, Science 2017

May 18, 2017

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability→

May 18, 2017/ Kartik Chandran

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao X et al, Cell 2017

May 18, 2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses→

May 18, 2017/ Kartik Chandran

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

May 05, 2016

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site→

May 05, 2016/ Kartik Chandran

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell KA et al, Cell Rep 2016

March 30, 2016

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→

March 30, 2016/ Kartik Chandran

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

February 09, 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway→

February 09, 2016/ Kartik Chandran

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

January 29, 2016

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses→

January 29, 2016/ Kartik Chandran

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

January 20, 2016

Cysteine cathepsin inhibitors as anti-Ebola agents→

January 20, 2016/ Kartik Chandran

Cysteine cathepsin inhibitors as anti-Ebola agents

van der Linden W et al, ACS Infect Dis 2016

December 23, 2015

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats→

December 23, 2015/ Kartik Chandran

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

July 22, 2015

Novel small molecule entry inhibitors of Ebola virus→

July 22, 2015/ Kartik Chandran

Novel small molecule entry inhibitors of Ebola virus

Basu A et al, J Infect Dis 2015

June 03, 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion→

June 03, 2015/ Kartik Chandran

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015